Scientist have found that rapamycin might slow periodontal disease! Rapamycin is an immune-suppressing drug currently used to prevent organ rejection in transplant recipients. It was hypothesized that aging contributes to periodontal disease, and that interventions that delay aging should also delay the progress of this disease. In the study done, a team measured the periodontal bone, or bone around the tooth, of the rapamycin-treated and untreated mice. They showed that the treated mice had more bone than the untreated mice, and had actually grown new bone during the period they were receiving rapamycin. Genetic sequencing of the bacteria in their mouths also revealed that the animals had fewer bacteria associated with gum disease and a mix of oral bacteria more similar to that found in healthy young mice. These results show that rapamycin has the potential to delay gum disease and possibly reverse the effects. More trials would be needed to determine any risks.
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